NOW's Folic Acid 800 mcg is a state of the art blend that includes 25 mcg of Vitamin B-12 for synergistic effect and quick absorption. When used in combination with vitamin B-12, folic acid may help facilitate the production of cellular energy. As part of a well-balanced diet that is low in saturated fat and cholesterol, Folic Acid, Vitamin B6 and Vitamin B12 may reduce the risk of vascular disease. FDA evaluated the above claim and found that, while it is known that diets low in saturated fat and cholesterol reduce the risk of heart disease and other vascular diseases, the evidence in support of the above claim is inconclusive.